XELATOTERAPIYADA QO`LLANILADIGAN ANTIDOTLAR TURLARI VA TIBBIYOTDAGI AHAMIYATI
Keywords:
Kalit so`zlar: xelatoterapiya, antidot, xelatlovchi agent, og`ir metallar, EDTA, dimercaprol, suktsimer, deferoksamin, koordinatsion birikma, kompleks hosil bo`lishi, organik sintez.Abstract
Annotatsiya. Mazkur maqolada xelatoterapiya usulining kimyoviy asoslari, og`ir metall ionlari bilan zaharlanishda qo`llaniladigan antidotlarning tuzilishi, sintez prinsiplari, metall ionlari bilan kompleks birikmalar hosil qilish mexanizmlari va tibbiyotdagi ahamiyati yoritilgan. Etilendiamintetraatsetat kislota (EDTA), dimerkaptopropanol (dimercaprol), dimerkaptosuksin kislota (DMSA, suktsimer), D-penitsillamin va deferoksamin kabi xelatlovchi moddalar tahlil qilingan. Shuningdek, xelatlovchi preparatlarning selektivligi, biologik samaradorligi, xavfsizligi va ularni takomillashtirishning istiqbolli yo`nalishlari ko`rib chiqilgan.
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