IDIOPATIK ODATIY HOMILA TASHLASH: ETIOLOGIYA VA PATOGENEZ HAQIDAGI ZAMONAVIY TASAVVURLAR (ADABIYOTLAR SHARHI)
Keywords:
Kalit so‘zlar: odatiy homila tashlash, idiopatik, tushuntirib bo‘lmaydigan, etiologiya, patogenez, aneuploidiya, endometriy.Abstract
Dolzarbligi. Odatiy homila tashlash (OHT) reproduktiv yoshdagi ayollarning 1-3 foiziga ta’sir qiladi va taxminan yarim hollarda sabab standart tekshiruvdan keyin ham aniqlanmay qoladi. Bunday holat idiopatik (tushuntirib bo‘lmaydigan) OHT deb ataladi.
Maqsad - idiopatik OHTning ta’rifi, tarqalishi, etiologiyasi va patogenezi haqidagi zamonaviy ma’lumotlarni umumlashtirish.
Material va usullar. PubMed, Scopus, Cochrane Library va eLIBRARY.ru bazalaridagi nashrlarning narrativ sharhi; klinik tavsiyalar, tizimli sharhlar va randomizatsiyalangan tadqiqotlarga ustuvorlik berildi.
Natijalar. Idiopatik OHT - bir jinsli bo‘lmagan guruh: unda asosan ona yoshi bilan bog‘liq embrion xromosoma anomaliyali yo‘qotishlar hamda endometriy retseptivligi buzilishi, immun disregulyatsiyasi, erkak omili va turmush tarzi roli muhokama qilinadigan euploid embrionlar yo‘qotilishi birga uchraydi.
Xulosalar. «Idiopatik OHT» tashxisi zamonaviy diagnostika imkoniyatlarining cheklanganligini aks ettiradi; istiqbollar endometriy, embrion aneuploidiyasi va immun profilni o‘rganish hamda ta’riflarni uyg‘unlashtirish bilan bog‘liq.
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