HOW DO PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES INTERACT DURING CYTOKINE STORM DEVELOPMENT IN COVID-19?
Abstract
Abstract: The cytokine storm during COVID-19 is associated with different types of cytokines. Especially, pro- and anti-inflammatory cytokines are the driving factors of storms. Some studies suggest that storms are linked with all of the cytokines, while others reveal that they depend on the specific ones, such as interleukin-6 and tumor necrosis factor alpha. This review, using PubMed and Google Scholar, examines the interaction between pro- and anti-inflammatory cytokines. This paper could help scientists and doctors to come to overall conclusions about cytokine interactions during COVID-19 infection.
References
1. National Cancer Institute. Cytokine // NCI Dictionary of Cancer Terms. – Available at: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cytokine
2. Cleveland Clinic. Cytokines: What They Are, Function & Types // Cleveland Clinic Health Library. – Available at: https://my.clevelandclinic.org/health/body/24585-cytokines
3. Al-Kuraishy H.M., Al-Gareeb A.I., Alkazmi L., et al. The potential nexus between helminths and SARS-CoV-2 infection: a literature review // Journal of Immunology Research. – 2023.
4. ScienceDirect. Cytokine-related immune responses in viral infections // Available at: https://www.sciencedirect.com/science/article/pii/S1359610124001047
5. ScienceDirect. Immune regulation and cytokine signalling in viral diseases // Available at: https://www.sciencedirect.com/science/article/abs/pii/S1043466623002983
6. ScienceDirect. Cytokine interactions in inflammatory diseases // Available at: https://www.sciencedirect.com/science/article/abs/pii/S0165247823001104
7. ScienceDirect. Cytokine-mediated immune responses in infection // Available at: https://www.sciencedirect.com/science/article/pii/S0168170223000539
8. ScienceDirect. Immune system responses in COVID-19 // Available at: https://www.sciencedirect.com/science/article/pii/S1319016421000165
9. Paranga B., et al. Cytokine storm and immune dysregulation in COVID-19 // International Journal of Molecular Sciences. – 2024.
10. Han H., Ma Q., Li C., et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors // Emerging Microbes & Infections. – 2020.
11. Dhar S.K., K V., Damodar S., Gujar S. Das. IL-6 and cytokine storm in COVID-19: mechanisms and therapeutic perspectives // Heliyon. – 2021.
12. Yang L., Liu S., Liu J., et al. COVID-19: immunopathogenesis and immunotherapeutics // Signal Transduction and Targeted Therapy. – 2021.
13. Azaiz R., et al. Cytokine storm in COVID-19: pathogenesis and overview of therapeutic strategies // Frontiers in Immunology. – 2022.
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