MITOCHONDRIAL DYSFUNCTION IN NEURODEGENERATIVE DISEASES: FROM ENERGY FAILURE TO NEURONAL DEATH

Authors

  • Alkov Ruslan Alimjonovich Author
  • Karimova Nargiza Erkinovna Author
  • Temirov Muhammad Alisher Ugli Author
  • Boymurodova Oybarchin Saidmurod qizi Author

Keywords:

Keywords: Neuroplasticity, Brain injury, Stroke, Synaptic plasticity, BDNF, Neurorehabilitation, Brain-computer interface

Abstract

Abstract 
Neuroplasticity  enables  the  brain  to  adapt  structurally  and  functionally  after 
injury.  Following  stroke,  traumatic  brain  injury,  and  other  neurological  insults, 
synaptic  remodeling,  axonal  sprouting,  cortical  reorganization,  and  glial  responses 
contribute  to  functional  recovery.  Rehabilitation,  neuromodulation,  brain-computer 
interfaces,  and  emerging  AI-based  approaches  aim  to  enhance  these  adaptive 
processes. This review summarizes key mechanisms of post-injury neuroplasticity and 
current therapeutic strategies for improving neurological recovery. 

References

1. Apostolova, N., & Victor, V. M. (2015). Molecular strategies for targeting

antioxidants to mitochondria: Therapeutic implications. Antioxidants & Redox

Signaling, 22(8), 686–729.

2. Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, M., Stevnsner,

T., Nilsen, H., Bohr, V. A., & Fang, E. F. (2017). Mitophagy in neurodegeneration and

aging. Neurochemistry International, 109, 202–209.

3. Gao, X.-Y., Yang, T., Gu, Y., & Sun, X.-H. (2022). Mitochondrial

dysfunction in Parkinson’s disease: From mechanistic insights to therapy. Frontiers in

Aging Neuroscience, 14, 885500.

4. Johri, A., & Beal, M. F. (2012). Mitochondrial dysfunction in

neurodegenerative diseases. The Journal of Pharmacology and Experimental

Therapeutics, 342(3), 619–630.

5. Klemmensen, M. M., Borrowman, S. H., Pearce, C., Pyles, B., & Chandra,

B. (2024). Mitochondrial dysfunction in neurodegenerative disorders.

Neurotherapeutics, 21(1), e00292.

6. Pantiya, P., Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2020).

Mitochondrial abnormalities in neurodegenerative models and possible interventions:

Focus on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease.

Mitochondrion, 55, 14–47.

7. Wang, Y., Xu, E., Musich, P. R., & Lin, F. (2019). Mitochondrial

dysfunction in neurodegenerative diseases and the potential countermeasure. CNS

Neuroscience & Therapeutics, 25(7), 816–824.

8. Wen, H., Deng, H., Li, B., Chen, J., Zhu, J., Zhang, X., Yoshida, S., &

Zhou, Y. (2025). Mitochondrial diseases: From molecular mechanisms to therapeutic

advances. Signal Transduction and Targeted Therapy, 10, e20443.

9. Williamson, M. G., Madureira, M., McGuinness, W., Heon-Roberts, R.,

Mock, E. D., Naidoo, K., et al. (2023). Mitochondrial dysfunction and mitophagy

defects in LRRK2-R1441C Parkinson’s disease models. Human Molecular Genetics,

32(18), 2808–2821.

10. Zhao, J., Wang, X., Huo, Z., Chen, Y., Liu, J., Zhao, Z., et al. (2022). The

impact of mitochondrial dysfunction in amyotrophic lateral sclerosis. Cells, 11(13),

2049.

Published

2026-09-05

How to Cite

Alkov Ruslan Alimjonovich, Karimova Nargiza Erkinovna, Temirov Muhammad Alisher Ugli, & Boymurodova Oybarchin Saidmurod qizi. (2026). MITOCHONDRIAL DYSFUNCTION IN NEURODEGENERATIVE DISEASES: FROM ENERGY FAILURE TO NEURONAL DEATH . TADQIQOTLAR, 93(1), 118-121. https://alpharesearchs.com/index.php/tad/article/view/4286