TIREOID GORMONLAR DISBALANSI SHAROITIDA SUT BEZIDAGI FIBROZ-KISTOZ O‘ZGARISHLARNING MORFOLOGIK XUSUSIYATLARI
Keywords:
Kalit so‘zlar: tireoid gormonlar, gipotireoz, sut bezi, fibroz-kistoz o‘zgarishlar, stromal fibroz.Abstract
Annotatsiya. Maqolada tireoid gormonlar disbalansi sharoitida sut bezida
yuzaga keladigan fibroz-kistoz o‘zgarishlarning morfologik va patogenetik
xususiyatlari tahlil qilingan. Sut bezi gormonga sezgir a’zo sifatida tireoid gormonlar,
estrogen, progesteron, prolaktin hamda mahalliy o‘sish omillarining o‘zaro ta’siri
ostida faoliyat ko‘rsatadi. Tireoid funksiyaning buzilishi sut bezi epitelial-stromal
tizimining gormonal javobini o‘zgartirib, terminal duktal-lobulyar birliklarda kistoz
kengayish, stromal fibroz, adenoz, epitelial giperplaziya va apokrin metaplaziya kabi
morfologik holatlarning shakllanishiga ko‘maklashishi mumkin.
References
ADABIYOTLAR RO`YXATI
1. Forsyth I. A. The mammary gland // Baillière’s Clinical Endocrinology and
Metabolism. — 2011. — Vol. 5, No. 4. — P. 809–832. — DOI: 10.1016/S0950-
351X(10)80016-3.
2. WHO Classification of Tumours Editorial Board. Breast Tumours. WHO
Classification of Tumours. 5th ed. Vol. 2. — Lyon: International Agency for Research
on Cancer, 2019. — ISBN 978-92-832-4500-1.
3. Bhargav P. R. K., Mishra A., Agarwal G., Agarwal A., Verma A. K., Mishra
S. K. Prevalence of hypothyroidism in benign breast disorders and effect of thyroxine
replacement on the clinical outcome // World Journal of Surgery. — 2009. — Vol. 33,
No. 10. — P. 2087–2093. — DOI: 10.1=007/s00268-009-0143-y.
4. Kohnepoushi P., Dehghanbanadaki H., Mohammadzedeh P., Nikouei M.,
Moradi Y. The effect of the polycystic ovary syndrome and hypothyroidism on the risk
of fibrocystic breast changes: a meta-analysis // Cancer Cell International. — 2022. —
Vol. 22. — Art. 125. — DOI: 10.1186/s12935-022-02547-5.
5. Quinn C. M., D’Arcy C., Wells C. Apocrine lesions of the breast // Virchows
Archiv. — 2022. — Vol. 480, No. 1. — P. 177–189. — DOI: 10.1007/s00428-021-
03185-4.
