HELICOBACTER PYLORI BILAN BOG'LIQ SURUNKALI ATROFIK GASTRIT VA OSHQOZON SARATONI XAVFI: ADABIYOTLAR SHARHI
Keywords:
Kalit so'zlar: surunkali atrofik gastrit, oshqozon saratoni xavfi, prekanseroz holat, Helicobacter pylori, ichak metaplaziyasi, epigenetik o'zgarishlar, hujayra qarishi, eradikatsiya terapiyasi.Abstract
ANNOTATSIYA
Surunkali atrofik gastrit (SAG) Helicobacter pylori (H. pylori) infeksiyasi bilan
chambarchas bog'liq bo'lib, oshqozon shilliq qavatining atrofiyasi va/yoki ichak
metaplaziyasi (IM) bilan tavsiflanadi. SAG ko'pincha oshqozon saratonining
prekanseroz holati sifatida qaraladi: H. pylori infeksiyasi Interleykin-8 (IL-8) kabi
yallig'lanish omillarini ishlab chiqarish orqali oshqozon shilliq qavatiga uzoq
muddatli ta'sir ko'rsatib, atrofiya va IM rivojlanishini hamda oshqozon saratoni
progressiyasini kuchaytiradi. Molekulyar biologiya nuqtai nazaridan, tobora ko'payib
borayotgan dalillar H. pylori ning SAGdan oshqozon saratoniga o'tishida NF-κB, miR-
204, miR-27a, hnRNPA2B1 va JARID1B ifodalanishini o'zgartirishda muhim rol
o'ynashini ko'rsatmoqda. Bundan tashqari, H. pylori Epstein-Barr virusi (EBV)
infeksiyasini kuchaytirishi va birgalikdagi infeksiya oshqozon saratoni xavfini yanada
oshirishi mumkin. Shuningdek, H. pylori hujayra qarishini (keksayishini) keltirib
chiqaradi, bu esa atrofiya progressiyasini tezlashtirib, oxir-oqibat oshqozon saratoni
xavfini oshiradi. Ushbu sharhda H. pylori bilan bog'liq SAGning saraton keltirib
chiqarish mexanizmlari, shuningdek oshqozon saratonini erta aniqlash va oldini olish
uchun nazariy asos yoritib berilgan.
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