SUBKLINIK GIPOTIREOZLI BEMORLARDA NEVROLOGIK BUZILISHLARNING UCHRASH CHASTOTASI, TURLARI VA OG‘IRLIK DARAJASI
Keywords:
Klinik-nevrologik tekshiruv, neyropsixologik testlar (Montreal Kognitiv Baholash Shkalasi — MoCA, Bosh og‘rig‘ini hayot faoliyatiga ta’siri HIT-6, visual Analog Shkala -VASh, vegetativ asab tizimini baholash), UTT natijalariga ko‘ra, asosiy guruhda doimiy charchoq 68 % (n=85), bosh og‘riqlari 44,8 % (n=56), uyqu buzilishlari 33,3% (n=42), periferik polineyropatiya 48,6% (n=72), kognitiv faoliyat buzilishi 28,8% (n=36) va mushaklardagi kuchsizlik 36% (n=45) bemorida aniqlandi. (r=0,64; p<0,01). Olingan natijalar subklinik gipotireozni o‘z vaqtida aniqlash va nevrologik asoratlarni profilaktika qilishda tireoid gormonal muvozanatni monitoring qilishning muhimligini tasdiqlaydi.Abstract
Ushbu ilmiy tadqiqot subklinik gipotireoz (SG) ga chalingan bemorlarda
nevrologik buzilishlarning uchrash chastotasi, sifat tarkibi va klinik og‘irlik darajasini
kompleks baholashga bag‘ishlangan. Tadqiqot 2023–2025 yillar davomida Respublika
Ixtisoslashtirilgan Endokrinologiya Ilmiy-Amaliy Tibbiyot Markazi Farg‘ona filialida
amalga oshirildi. Asosiy guruhga tireoid stimullovchi gormon (TSG) darajasi 4,5–10,0
mIU/L oralig‘ida bo‘lgan, erkin T4 (fT4) esa me’yor doirasida saqlanib qolgan 125
nafar bemor kiritildi; nazorat guruhini 67 nafar sog‘lom shaxs tashkil etdi.
References
1. Bauer M., Goetz T., Glenn T., Whybrow P.C. The thyroid-brain interaction in
thyroid disorders and mood disorders. J Neuroendocrinol. 2008;20(10):1101–1114.
DOI: 10.1111/j.1365-2826.2008.01773.x
2. Bono G., Fancellu R., Blandini F., Santoro G., Mauri M. Cognitive and
affective status in mild hypothyroidism and interactions with L-thyroxine treatment.
Acta Neurol Scand. 2004;110(1):59–66. DOI: 10.1111/j.1600-0404.2004.00262.x
3. Constant E.L., de Volder A.G., Ivanoiu A., Bol A., Labar D., Seghers A., et al.
Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission
tomography study. J Clin Endocrinol Metab. 2001;86(8):3864–3870. DOI:
10.1210/jcem.86.8.7739
4. Dyck P.J., Lambert E.H. Polyneuropathy associated with hypothyroidism. J
Neuropathol Exp Neurol. 1970;29(4):631–658. DOI: 10.1097/00005072-197010000
00009
5. Fountoulakis K.N., Iacovides A., Grammaticos P., Kaprinis G.S., Bech P.
Thyroid function in clinical subtypes of major depression: an exploratory study. BMC
Psychiatry. 2004;4(6). DOI: 10.1186/1471-244X-4-6
6. Garber J.R., Cobin R.H., Gharib H., Hennessey J.V., Klein I., Mechanick J.I.,
et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the
American Association of Clinical Endocrinologists and the American Thyroid
Association. Endocr Pract. 2012;18(6):988–1028. DOI: 10.4158/EP12280.GL
7. Haggerty J.J.Jr., Prange A.J.Jr. Borderline hypothyroidism and depression.
Annu Rev Med. 1995;46:37–46. DOI: 10.1146/annurev.med.46.1.37
