ENDOMETRIOZ VA BEPUSHT BEMORLARDA LETROZOL BILAN TAYYORLOV TERAPIYASINING EKSTRAKORPORAL URUG‘LANTIRISH (EKO) NATIJALARIGA TA’SIRI
Keywords:
Endometrioz, bepushtlik, Letrozol, aromataza ingibitorlari, EKO (ekstrakorporal urug‘lantirish), endometriy retseptivligini oshirish, implantatsiya darchasi, ootsitlar sifati,Abstract
Ushbu ilmiy maqolada endometrioz bilan bog‘liq bepushtlikka ega
bo‘lgan ayollarda ekstrakorporal urug‘lantirish (EKO) protokolidan oldin Letrozol
(aromataza ingibitori) bilan tayyorlov terapiyasining samaradorligi va xavfsizligi batafsil
tahlil qilinadi. "Siz Ona bo‘lasiz" EKO markazi klinikasida o‘tkazilgan tadqiqot 180 nafar
endometrioz tashxisi qo‘yilgan bemorlarni o‘z ichiga olib, ularning retseptorlar sezgirligi,
endometriy qalinligi va implantatsiya ko‘rsatkichlari solishtirildi. Natijalar Letrozol
tayyorlovi endometriy retseptivligini sezilarli darajada oshirishi va EKO muvaffaqiyatini
16.7% ga oshirishini ko‘rsatdi.
References
1. Al-Sunaidi M., Tulandi T. (2021). Pretreatment with aromatase inhibitors in IVF for
women with endometriosis: A systematic review. Fertility and Sterility, 115(4), 982-990.
2. Abu-Hashim H. (2022). Aromatase inhibitors for IVF in endometriosis-associated
infertility: Mechanisms and clinical evidence. Reproductive BioMedicine Online, 44(2),
312-325.
3. Garcia-Velasco J. A., et al. (2020). Endometrial receptivity and aromatase
expression in patients with severe endometriosis under IVF protocols. Human
Reproduction, 35(8), 1845-1854.
4. Ferrero S., Evangeliou A., et al. (2023). Letrozole pretreatment improves
implantation rates in endometriosis patients undergoing ICSI. European Journal of
Obstetrics & Gynecology, 278, 114-121.
5.
Tashkent Medical Academy Practice Guidelines (2025). Endometrioz va
bepushtlikni davolashda zamonaviy reproduktiv usullar. Toshkent, 45-58 b.
6. Bulun S. E., et al. (2019). Endometriosis and aromatase: Molecular pathophysiology
and clinical implications. Endocrine Reviews, 40(4), 1048-1079.