QANDLI DIABET KASALLIGI BILAN OG‘RIGAN BEMORLARDA GAPTOGLOBIN GENOTIPI VA YURAK-QON TOMIR KASALLIKLARI XAVFI BILAN BOG‘LIQ AHAMIYATI.
Keywords:
E vitamini diabetga chalingan va 2-2 genotipga ega bemorlarda yurak-qon tomir hodisalarini kamaytirishi ko‘rsatilgan, ammo bunday terapiyani qo‘llashning xavfsizligi hali noma’lum. Ilgari glyukozani agressivroq nazorat qilishning foyda va xavflarini baholash uchun o'tkazilgan muhim tadqiqotning post-hoc tahlili shuni ko‘rsatdiki, diabet bilan kasallangan va 2-2 genotipga ega bemorlarda yurak-qon tomir xavfini kamaytiruvchi foyda mavjud bo‘lishi mumkin, bu boshqa genotipli bemorlarda kuzatilmaydi.Abstract
Gaptoglobin ( Hp) genetik jihatdan polimorf bo‘lib, uchta asosiy
genotipga ega: Hp 1-1, 2-1 va 2-2. Har bir genotip fenotipik jihatdan Hp tuzilishi va
uning asosiy funksiyasi-eski qizil qon hujayralaridan (eritrotsitlardan) bo‘shagan erkin
gemoglobinni (Hb) yo‘q qilish qobiliyati bilan farq qiladi. Qandli diabet bilan
kasallangan bemorlarda 2-2 genotip mavjud bo‘lsa, ularning yurak-qon tomir
kasalliklari xavfi boshqa genotiplar yoki diabet bo‘lmagan bemorlarga nisbatan yuqori
bo‘lishi mumkin. Bu xavf glyukozani nazorat qilish darajasi yomonlashganda yanada
oshadi. Ushbu xavfning aniq mexanizmi noma’lum bo‘lsa-da, bir nechta taklif qilingan
sabablar mavjud.
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