MORPHOFUNCTIONAL CHANGES IN THE HEART UNDER EXPERIMENTAL SLEEP DEPRIVATION AND MORPHOLOGICAL BASIS OF THEIR CORRECTION
Keywords:
sleep deprivation, heart, myocardium, cardiomyocytes, morphometry, vascular changes, connective tissue, experimental study, morphological correction.Abstract
Sleep is an essential physiological process involved in maintaining
cardiovascular homeostasis, metabolic balance, neuroendocrine regulation, and tissue
recovery. Persistent sleep deprivation is considered an important stress factor that may
adversely affect the cardiovascular system. Experimental studies indicate that
insufficient sleep can be accompanied by structural and functional changes in the
myocardium, vascular disorders, alterations in cardiomyocyte morphology, and
changes in the interstitial tissue. The aim of this study was to analyze the
morphofunctional changes occurring in the heart under experimental sleep deprivation
and to assess the morphological basis of their correction. Experimental sleep
deprivation may lead to changes in myocardial architecture, cardiomyocyte size,
vascular components, and connective tissue organization. These structural changes
may be associated with disturbances in myocardial contractile activity and tissue
adaptation. Morphological assessment of the myocardium provides an important basis
for understanding the mechanisms of cardiovascular adaptation to prolonged sleep loss
and evaluating the effectiveness of corrective interventions. The study of
morphological and morphometric parameters can therefore contribute to the
development of scientifically grounded approaches to the prevention and correction of
cardiovascular changes associated with sleep deprivation.
References
Experimental sleep deprivation is associated with structural
alterations in the myocardium involving cardiomyocytes, microcirculatory vessels,
and the interstitial component of cardiac tissue. Morphometric analysis provides an
objective approach for identifying and quantifying these changes. The morphological
assessment of the heart can serve as an important component in evaluating the effects
of prolonged sleep deprivation and the efficacy of corrective interventions. Partial
normalization of myocardial structural parameters following correction may indicate
improvement of tissue adaptation and preservation of myocardial architecture. The
results support the importance of an integrated morphological approach for studying
cardiovascular consequences of sleep deprivation. Further investigations combining
histological, morphometric, biochemical, and functional methods may provide a more
comprehensive understanding of the mechanisms involved and help establish
evidence-based approaches to correction.
