INSULTDA KALSIY GOMEOSTAZINING BUZILISHI VA APOPTOZ MEXANIZMLARI
Keywords:
Kalit so‘zlar: insult, kalsiy gomeostazi, apoptoz, neyron, ishemiya, glutamat, eksitotoksiklik, mitoxondriya, oksidlovchi stress, neyroproteksiya.Abstract
Annotatsiya: Insult bosh miya qon aylanishining o‘tkir buzilishi bo‘lib, nerv hujayralarining shikastlanishi, nevrologik faoliyatning izdan chiqishi va turli darajadagi funksional cheklanishlarga olib kelishi mumkin. Ishemik insultda miya to‘qimasiga kislorod va glyukoza yetkazib berilishining kamayishi hujayra energetik almashinuvini buzadi, natijada hujayra ichida kalsiy ionlari miqdori ortadi va apoptoz jarayonlari faollashadi. Kalsiy gomeostazining buzilishi glutamat eksitotoksikligi, mitoxondriyal disfunksiya, oksidlovchi stress va hujayra o‘limi mexanizmlari bilan chambarchas bog‘liq. Ushbu maqolada insult vaqtida kalsiy ionlari muvozanatining buzilish sabablari, apoptozning molekulyar mexanizmlari hamda mazkur jarayonlarning nerv to‘qimasi zararlanishidagi ahamiyati yoritiladi. Shuningdek, neyroprotektiv yondashuvlar va insultni erta tashxislashning ahamiyati muhokama qilinadi.
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